A pick-up line is ONE way to conversation, but it's usually not an EFFECTIVE way. About a year ago I was dancing at a local club. My friend Dave introduced me to a woman named Alexis. After we shook hands she asked, "So Scott...do you have any friends named Alexis?"
"Uh, well yeah...there was a girl I went to college with named Alexis."
"Okay, well let me ask you this," she said as she pressed herself against my body, "Have you ever RIDDEN in Alexis before?"
If you want read some other ineffective ways to start conversations (do these EVER work?), check out Dan Hersam's blog. Also, in an old Dave Barry article, the humorist had the following to say about the sacred art of the pick-up line:
LET ME ASK YA THIS...
What's the best/worst pick-up line you've ever heard?
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Author/Speaker/That guy with the nametag